Pore confinement and surface charge effects in protein-mesoporous silica nanoparticles formulation for oral drug delivery
نویسندگان
چکیده
منابع مشابه
pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery
The application of nanotechnology to medicine constitutes a major field of research nowadays. In particular, the use of mesoporous silica and carbon nanoparticles has attracted the attention of numerous researchers due to their unique properties, especially when applied to cancer treatment. Many strategies based on stimuli-responsive nanocarriers have been developed to control the drug release ...
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Recent breakthroughs in the synthesis of mesoporous silica materials with controlled particle size, morphology, and porosity, along with their chemical stability, has made silica matrices highly attractive as the structural basis for a wide variety of nanotechnological applications such as adsorption, catalysis, sensing, and separation. In addition, we and others have discovered that surface-fu...
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Novel mesoporous silica nanoparticles (MSNs) responsive to multiple biological stimuli (pH and enzymes) were prepared through conjugation with a structure modified soy protein isolate. The particles show an extremely high pro-drug (sulfasalazine) loading with programmable drug release in simulated gastrointestinal fluid.
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Larissa Miller,1 Gordon Winter,2 Benjamin Baur,2 Barbara Witulla,2 Christoph Solbach,2 Sven Reske,2,* Mika Lindén1,* 1 Department of Inorganic Chemistry II, University Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, Germany 2 Clinic for Nuclear Medicine, University Ulm, Albert-Einstein-Allee 23, D-89081 Ulm, Germany Corresponding author e-mail addresses: [email protected], [email protected]
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Drug molecules with lack of specificity and solubility lead patients to take high doses of the drug to achieve sufficient therapeutic effects. This is a leading cause of adverse drug reactions, particularly for drugs with narrow therapeutic window or cytotoxic chemotherapeutics. To address these problems, there are various functional biocompatible drug carriers available in the market, which ca...
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ژورنال
عنوان ژورنال: Microporous and Mesoporous Materials
سال: 2020
ISSN: 1387-1811
DOI: 10.1016/j.micromeso.2020.110482